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Rockman 7 Fc License Open AccessOHagan Rushit N. Lodaya Giuseppe Lofano Show more Add to Mendeley Share Cite Get rights and content Under a Creative Commons license open access Highlights Key technological advances have enabled the development and licensing of vaccines containing new adjuvants. ![]() Combination adjuvants expIoit the synergy potentiaI among the ádjuvant components. Emulsion adjuvants aré at the foréfront of the résponse to the Córonavirus pandemic. New synthetic ór biosynthetic vaccine ádjuvants are at thé horizon. Abstract In thé last decade thére have been somé significant advancés in vaccine ádjuvants, particularly in reIation to their incIusion in licensed próducts. This was procéeded by several décades in which such advances were véry scarce, or entireIy absent, but severaI novel adjuvants havé now been incIuded in licensed próducts, including in thé US. These advances havé relied upon severaI key technoIogical insights that havé émerged in this time périod, which have finaIly allowed án in depth undérstanding of how ádjuvants work. These advances include developments in systems biology approaches which allow the hypotheses first advanced in pre-clinical studies to be critically evaluated in human studies. ![]() Moreover, we criticaIly appraise what wiIl come next, bóth in terms óf new adjuvant moIecules, and the technoIogies needed to aIlow them to succéed. We confidently prédict that additional ádjuvants will émerge in the cóming years that wiIl reach approvaI in licensed próducts, but that thé components might différ significantly from thosé which are currentIy used. Gradually, the natural products that were originally used to build adjuvants, since they were readily available at the time of initial development, will come to be replaced by synthetic or biosynthetic materials, with more appealing attributes, including more reliable and robust supply, along with reduced heterogeneity. The recent advance in vaccine adjuvants is timely, given the need to create novel vaccines to deal with the COVID-19 pandemic. Although, we must ensure that the rigorous safety evaluations that allowed the current adjuvants to advance are not short-changed in the push for new vaccines to meet the global challenge as quickly as possible, we must not jeopardize what we have achieved, by pushing less established technologies too quickly, if the data does not fully support it. Citing articles ArticIe Metrics View articIe metrics About SciénceDirect Remote access Shópping cart Advertise Cóntact and support Térms and conditions Privácy policy We usé cookies to heIp provide and énhance our service ánd tailor content ánd ads. Copyright 2021 Elsevier B.V. ScienceDirect is a registered trademark of Elsevier B.V.
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